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Title: Dyserythropoiesis and ineffective erythropoiesis in Plasmodium vivax malaria
Authors: S. N. Wickramasinghe
Sornchai Looareesuwan
Bussarin Nagachinta
N. J. White
St Mary's Hospital London
Mahidol University
Paholpolpayuhasena Hospital
University of Oxford
Keywords: Medicine
Issue Date: 1-Jan-1989
Citation: British Journal of Haematology. Vol.72, No.1 (1989), 91-99
Abstract: Summary. Nine Thai adults with P. vivax malaria were investigated. Light and electron microscope studies of marrow aspirates revealed morphological evidence of dyserythro‐poiesis in six of them, Dyserythropoiesis was most marked in the four most anaemic patients. In these four patients the electron microscope also revealed the presence of erythro‐blasts at various stages of degradation within the cytoplasm of macrophages. Neither the dyserythropoiesis nor the ineffective erythropoiesis could be attributed to a deficiency of vitamin B 12 , folate or iron. The abnormalities of erythropoiesis seemed to result from the P. vivax infection itself. Other bone marrow reactions seen in this infection included macrophage hyperplasia, plasmacytosis and increased eosinophil granulocytopoiesis. Unlike in severe P. falciparum malaria, the microvasculature of the marrow was not obstructed by parasitized red cells. Copyright © 1989, Wiley Blackwell. All rights reserved
ISSN: 13652141
Appears in Collections:Scopus 1969-1990

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