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Title: Breast cancer and combined oral contraceptives: Results from a multinational study
Authors: Geoffrey Berry
Robert MacLennan
Rodney Shearman
Tatiana Jelihovsky
Joan Cooper Booth
Ramiro Molina
Luis Martinez
Oriana Salas
Alfredo Dabancens
Chen Zhiheng
Tao Yun
Hu Yong Wei
Alvaro Cuadros
Nubia Aristizabal
K. Ebeling
P. Nishan
D. Kunde
Baruch Modan
Elaine Ron
Ester Alfandary
J. G. Mati
Patrick Kenya
Alfred Kungu
D. Gatei
Hector Rodriguez Cuevas
Socorro Benavides Salazar
Antonio Palet
Patricia Ontiveros
Ruben A. Apelo
Julietta R. de la Cruz
Jose Baens
Benita Javier
Suporn Silpisornkosol
Tieng Pardthaisong
Nimit Martin
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrichanalai
Prasarn Jimakorn
Suporn Koetsawang
Daungdao Rachawat
Nivat Chantarakul
Helge Stalsberg
David B. Thomas
Elizabeth A. Noonan
Susan Holck
The University of Sydney
Facultad de Medicina de la Universidad de Chile
Shanghai Institute of Planned Parenthood Research
Hospital Universitario
Akademie der Wissenschaften der DDR
Chaim Sheba Medical Center Israel
University of Nairobi
Hospital General de Mexico
University of the Philippines Manila
Chiang Mai University
Chulalongkorn University
Mahidol University
Universitetet i Tromso
Fred Hutchinson Cancer Research Center
Organisation Mondiale de la Sante
Hospital del Salvador
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-1990
Citation: British Journal of Cancer. Vol.61, No.1 (1990), 110-119
Abstract: A collaborative, hospital-based case-control study was conducted at 12 participating centres in 10 countries. Based on data from personal interviews of 2, 116 women with newly diagnosed breast cancer and 12,077 controls, the relative risk of breast cancer in women who ever used oral contraceptives was estimated to be 1.15 (1.02, 1.29). Estimated values of this relative risk based on data from three developed and seven developing countries were 1.07 (0.91, 1.26) and 1.24 (1.05, 1.47) respectively; these estimates are not significantly different (P = 0.22). Estimates for women under and over age 35 were 1.26 (0.95, 1.66) and 1.12 (0.98, 1.27), respectively, and these estimates are also not significantly different (P= 0.38). Risk was highest in recent and current users and declined with time since last use regardless of duration of use. Risk did not increase with duration of use after stratifying on time since last use. Risk did not increase significantly with increasing duration of use before age 25 or before a first live birth. However, a relative risk of 1.5 that was of borderline statistical significance was observed in women who used oral contraceptives for more than 2 years before age 25. No single source of bias or confounding was identified that could explain the small increases in risk that were observed. Chance alone is also an unlikely explanation. The results could be due to a combination of chance and potential sources of bias, or they could represent a weak causal relationship. © Macmillan Press Ltd., 1990.
ISSN: 15321827
Appears in Collections:Scopus 1969-1990

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