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Title: Antibodies that protect humans against plasinodium lalciparum blood stages do not on their own inhibit parasite growth and invasion in vitroy but act in cooperation with monocytes
Authors: Hasnaa Bouharoun-Tayoun
Phanorsi Attanath
Arunee Sabchareon
Tan Chongsuphajaisiddhi
Pierre Druilhe
Institut Pasteur, Paris
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-1990
Citation: Journal of Experimental Medicine. Vol.172, No.6 (1990), 1633-1641
Abstract: IgG extracted from the sera of African adults immune to malaria were injected intravenously into eight Plasmodium falcipamm-infected nonimmune Thai patients. Clinical and parasitological improvement was reproducibly obtained in each case. After the disappearance of the transferred Ig, recrudescent parasites were equally susceptible to the same Ig preparation. High levels of antibodies to most parasite proteins were detected by Western blots in the receivers’ sera (taken before transfer) as in the donors’ Ig, thus indicating that the difference was qualitative rather than quantitative between donors and receivers. In vitro, the clinically effective Ig had no detectable inhibitory effect on either penetration or intra-erythrocytec development of the parasite. On the contrary, they sometimes increased parasite growth. In contrast, these IgG, as the receivers’ Ig collected 4 d after transfer, but not those collected before transfer, proved able to exert an antibodydependent cellular inhibitory (ADCI) effect in cooperation with normal blood monocytes. Results were consistent among the seven isolates studied in vitro, as with the recrudescent parasites. Thus, the results obtained in the ADCI assay correlate closely with clinical and parasitological observations. © 1990, Rockefeller University Press., All rights reserved.
ISSN: 15409538
Appears in Collections:Scopus 1969-1990

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