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Title: Human cerebral malaria in Thailand: A clinico-pathological correlation
Authors: Mario Riganti
Emsri Pongponratn
Tatsuya Tegoshi
Sornchai Looareesuwan
Benjanee Punpoowong
Masamichi Aikawa
Mahidol University
Case Western Reserve University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1990
Citation: Immunology Letters. Vol.25, No.1-3 (1990), 199-205
Abstract: Based on the cerebral malaria coma scale, 39 falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups of patients that had either cerebral malaria or non-cerebral malaria. We then studied significant pathological differences, such as parasitized erythrocyte (PRBC) sequestration, ring hemorrhages and cerebral edema, between these two groups in order to investigate the correlation between the clinical coma scale and pathological findings. Patients with a coma grade of 2 and higher were designated as having cerebral malaria, and had erythrocyte PRBC sequestration in cerebral microvessels. Ninety four percent (94%) of cerebral microvessels showed PRBC sequestration when quantitatively analyzed. On the other hand, only 13% of cerebral microvessels showed sequestration in non-cerebral malaria patients with a coma grade of 1 and lower, although some degree of PRBC sequestration was found in 50% of these patients. Our study, therefore, clearly demonstrated that the degree of the PRBC sequestration in cerebral microvessels appeared to correlate closely with the clinical coma scale. © 1990.
ISSN: 01652478
Appears in Collections:Scopus 1969-1990

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