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Title: The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria
Authors: D. Waller
S. Krishna
N. J. White
A. Jammeh
D. Kwiatkowski
N. J. White
J. Karbwang
P. Molunto
Nuffield Department of Clinical Medicine
Hammersmith Hospital
Royal Victoria Teaching Hospital Gambia
Medical Research Council Laboratories Gambia
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1990
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.84, No.4 (1990), 488-491
Abstract: Plasma quinine concentrations were measured in 21 Gambian children with severe falciparum malaria after intramuscular administration of a 20 mg (salt) per kg loading dose of quinine dihydrochloride followed by 10 mg/kg at 12 h intervals. Quinine was well absorbed reaching mean peak concentrations of 15·6 (standard deviation [SD] 4·5) mg/litre in a median time of 3 h (range 1-6 h). A one compartment model was fitted to the plasma concentration-time profile. The mean estimated systemic clearance (C1/F) was 0·89 (SD 0·81) ml/kg/min and the mean elimination half life was 18·8 (SD 8·0) h. Two patients, one of whom died, had low plasma quinine levels which remained below 10 mg/litre. Mean peak and trough plasma concentrations after subsequent intramuscular doses ranged between 11·1 and 15·1 mg/litre. In most cases this dose regimen provided a satisfactory profile of blood concentrations for the treatment of severe malaria in children. © 1990, Roy al Society of Tropical Medicine and Hygiene. All rights reserved.
ISSN: 18783503
Appears in Collections:Scopus 1969-1990

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