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Title: Hemoglobin dhonburi α<inf>2</inf>β<inf>2</inf>126 (H4) Val → Gly: A new unstable β variant producing a β‐thalassemia intermedia phenotype in association with β°‐Thalassemia
Authors: J. Bardakdjian‐Michau
J. Delanoe‐Garin
C. Lacombe
Y. Blouquit
J. Riou
F. Galacteros
S. Fucharoen
P. Winichagoon
P. Wasi
J. Kister
Hopital Henri Mondor
Faculty of Medicine, Siriraj Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1990
Citation: American Journal of Hematology. Vol.35, No.2 (1990), 96-99
Abstract: While investigating the mechanism of a β‐thalassemia intermedia phenotype in a 34 year old Thai male, a new Hb variant β 126 Val → Gly named Hb Dhonburi was discovered. Genetic and structural studies revealed the existence of a β°‐thalassemia genotype in association with the β variant. The new variant is unstable but exhibits normal oxygen binding properties. Hb Dhonburi was also discovered in the mother of the propositus in association with Hb E. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
ISSN: 10968652
Appears in Collections:Scopus 1969-1990

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