Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/16170
Title: Hepatic mitochondrial function and lysosomal enzyme activity in ethanol-potentiated aflatoxin B1 hepatotoxicity
Authors: Chaivat Toskulkao
Thirayudh Glinsukon
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1990
Citation: Toxicology Letters. Vol.52, No.2 (1990), 179-190
Abstract: The possible role of hepatic mitochondrial function and lysosomal enzyme activity in ethanol-enhanced aflatoxin B 1 (AFB 1 ) hepatotoxicity was studied in male rats. Hepatic ATP content was significantly decreased in rats treated with ethanol (4.0 g/kg body wt.) and AFB 1 (2.0 mg/kg body wt.) compared with rats treated with AFB 1 alone at 12-72 h after AFB 1 administration. The decrease in hepatic ATP content was due to the decrease in the activity of NADH-cytochrome c reductase whereas cytochrome oxidase activity did not differ in rats treated with ethanol and AFB 1 when compared to AFB 1 alone. Total and free activities of hepatic lysosomal enzymes (glucuronidase, arylsulfatase and acid phosphatase) were significantly increased in rats treated with ethanol and AFB 1 at 24-36 h after AFB 1 administration when compared to AFB 1 alone. The increase in hepatic lysosomal enzyme activities correlated well with the increase in the lipid peroxide level of lysosomes in rats treated with ethanol and AFB 1 . These findings indicate that the decrease in hepatic mitochondrial respiratory enzyme activities and the increase in lipid peroxide level of lysosomes might lead to a decrease in hepatic ATP content, and that the increase in the activities of hepatic lysosomal enzymes, respectively, enhance the AFB 1 hepatotoxicity of ethanol. © 1990.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025352977&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/16170
ISSN: 03784274
Appears in Collections:Scopus 1969-1990

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