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Title: Antiserum to the gp116 glycoprotein of yellow head virus neutralizes infectivity in primary lymphoid organ cells of Penaeus monodon
Authors: Wanchai Assavalapsakul
Witoon Tirasophon
Sakol Panyim
Mahidol University
Keywords: Agricultural and Biological Sciences
Issue Date: 25-Jan-2005
Citation: Diseases of Aquatic Organisms. Vol.63, No.1 (2005), 85-88
Abstract: Yellow head virus (YHV) is an invertebrate nidovirus that has caused mass mortality of cultured Penaeus monodon in Asia. In this study, we investigated whether mouse polyclonal anti-serum raised against the YHV gp116 or gp64 structural glycoproteins could neutralize YHV infectivity as determined using an in vitro quantal assay in primary cultures of lymphoid organ cells. Anti-gp116 antiserum showed virus-neutralizing activity whereas anti-gp64 antiserum failed to inhibit infection. The results suggest that gp116 antiserum blocks binding of virions to cellular receptors to facilitate YHV entry into lymphoid organ cells.
ISSN: 01775103
Appears in Collections:Scopus 2001-2005

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