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Title: 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?
Authors: Porntep Chomcheon
Suthep Wiyakrutta
Nongluksna Sriubolmas
Nattaya Ngamrojanavanich
Duangnate Isarangkul
Prasat Kittakoop
Chulalongkorn University
Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2005
Citation: Journal of Natural Products. Vol.68, No.7 (2005), 1103-1105
Abstract: 3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 μM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1). © 2005 American Chemical Society and American Society of Pharmacognosy.
ISSN: 01633864
Appears in Collections:Scopus 2001-2005

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