Please use this identifier to cite or link to this item:
|Title:||Hb Kurosaki [α7(A5)Lys→Glu (4AG→GAG)]: An α2-globin gene mutation found in Thailand|
Chulabhorn Research Institute
The Institute of Science and Technology for Research and Development, Mahidol University
|Keywords:||Biochemistry, Genetics and Molecular Biology;Medicine|
|Citation:||Hemoglobin. Vol.29, No.2 (2005), 155-159|
|Abstract:||Hb Kurosaki [α7(A5)Lys→Glu (AAG→GAG)], has been found for the first time in Thailand. The 30-year-old Thai male had a normal hematological profile at the steady state, but showed an abnormal hemoglobin (Hb) present at a level of 28%. Protein characterization was performed by automated sequencer analysis of the abnormal α-globin chain and amino acid analysis of the abnormal αT-1,2 peptide. Direct DNA sequence analysis of selectively amplified segments of the α1 and α2 genes showed that codon 7 of the α2-globin gene was heterozygous for AAG (Lys) and GAG (Glu). This was confirmed by restriction endonuclease digestion with Eco31I. Copyright © 2005 Taylor & Francis, Inc.|
|Appears in Collections:||Scopus 2001-2005|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.