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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/16342
Title: Hb Kurosaki [α7(A5)Lys→Glu (4AG→GAG)]: An α2-globin gene mutation found in Thailand
Authors: Lukana Ngiwsara
Chantragan Srisomsap
Pranee Winichagoon
Suthat Fucharoen
Bussara Sae-Ngow
Jisnuson Svasti
Chulabhorn Research Institute
The Institute of Science and Technology for Research and Development, Mahidol University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 30-May-2005
Citation: Hemoglobin. Vol.29, No.2 (2005), 155-159
Abstract: Hb Kurosaki [α7(A5)Lys→Glu (AAG→GAG)], has been found for the first time in Thailand. The 30-year-old Thai male had a normal hematological profile at the steady state, but showed an abnormal hemoglobin (Hb) present at a level of 28%. Protein characterization was performed by automated sequencer analysis of the abnormal α-globin chain and amino acid analysis of the abnormal αT-1,2 peptide. Direct DNA sequence analysis of selectively amplified segments of the α1 and α2 genes showed that codon 7 of the α2-globin gene was heterozygous for AAG (Lys) and GAG (Glu). This was confirmed by restriction endonuclease digestion with Eco31I. Copyright © 2005 Taylor & Francis, Inc.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=18844422757&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/16342
ISSN: 03630269
Appears in Collections:Scopus 2001-2005

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