Please use this identifier to cite or link to this item:
|Title:||A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans|
|Keywords:||Biochemistry, Genetics and Molecular Biology;Environmental Science;Immunology and Microbiology;Mathematics;Medicine;Neuroscience;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Mathematical Medicine and Biology. Vol.22, No.1 (2005), 15-33|
|Abstract:||The present work develops and analyses a model system of delay-differential equations which describes the core dynamics of the stress-responsive hypothalamus-pituitary-adrenal axis. This neuroendocrine ensemble exhibits prominent pulsatile secretory patterns governed by nonlinear and time-delayed feedforward and feedback signal interchanges. Formulation and subsequent bifurcation analysis of the model provide a qualitative and mathematical frame work for a better understanding of the delayed responsive mechanisms as well as the dynamic variations in different pathological situations. © The Author 2005. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All Rights Reserved.|
|Appears in Collections:||Scopus 2001-2005|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.