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|Title:||Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation - amination - Michael addition cascade|
University of Leeds
Johnson Matthey Plc
|Citation:||Canadian Journal of Chemistry. Vol.83, No.6-7 (2005), 990-1005|
|Abstract:||We herein describe a novel palladium catalysed three-component cascade process involving carbonylation of an aryl iodide to generate an acyl palladium(II) species that is intercepted by a primary aliphatic or aromatic amine, amide, or sulfonamide followed by intramolecular Michael addition to furnish N-substituted isoindolinones in good yield. Overall, the cascade results in the formation of one C-C and two C-N bonds, one ring and one stereocentre. © 2005 NRC Canada.|
|Appears in Collections:||Scopus 2001-2005|
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