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Title: Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation - amination - Michael addition cascade
Authors: Ronald Grigg
Xinjie Gai
Tossapol Khamnaen
Shuleewan Rajviroongit
Visuvanathar Sridharan
Lixin Zhang
Simon Collard
Ann Keep
University of Leeds
Mahidol University
Johnson Matthey Plc
Keywords: Chemical Engineering;Chemistry
Issue Date: 1-Jun-2005
Citation: Canadian Journal of Chemistry. Vol.83, No.6-7 (2005), 990-1005
Abstract: We herein describe a novel palladium catalysed three-component cascade process involving carbonylation of an aryl iodide to generate an acyl palladium(II) species that is intercepted by a primary aliphatic or aromatic amine, amide, or sulfonamide followed by intramolecular Michael addition to furnish N-substituted isoindolinones in good yield. Overall, the cascade results in the formation of one C-C and two C-N bonds, one ring and one stereocentre. © 2005 NRC Canada.
ISSN: 00084042
Appears in Collections:Scopus 2001-2005

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