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Title: Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure
Authors: Chutima Kumkhaek
Kooruethai Phra-Ek
Laurent Rénia
Pratap Singhasivanon
Sornchai Looareesuwan
Chakrit Hirunpetcharat
Nicholas J. White
Alan Brockman
Anne Charlotte Grüner
Nicolas Lebrun
Ali Alloueche
François Nosten
Srisin Khusmith
Georges Snounou
Mahidol University
Shoklo Malaria Research Unit
Universite Paris Descartes
Churchill Hospital
Novartis Immunobiological Research Institute
Institut Pasteur, Paris
Museum National d'Histoire Naturelle
CNRS Centre National de la Recherche Scientifique
Keywords: Immunology and Microbiology
Issue Date: 15-Sep-2005
Citation: Journal of Immunology. Vol.175, No.6 (2005), 3935-3939
Abstract: Protective cellular immune responses depend on MHC presentation of pathogen-derived Ag fragments. MHC diversity renders this process sensitive to point mutations coding for altered amino acid sequence of the short target Ag-derived peptides epitopes. Thus, in a given host, a pathogen with an altered epitope sequence will be more likely to escape detection and elimination by the immune system. At a population level, selection by immune pressure will increase the likelihood of polymorphism in important pathogen antigenic epitopes. This mechanism of immune evasion is found in viruses and other pathogens. The detection of polymorphic hot spots in an Ag is often taken as a strong indication of its role in protective immunity. We provide evidence that polymorphisms in the T cell epitopes of a malaria vaccine candidate are unlikely to have been selected by immune pressure in the human host. Copyright © 2005 by The American Association of Immunologists, Inc.
ISSN: 00221767
Appears in Collections:Scopus 2001-2005

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