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dc.contributor.authorChutima Kumkhaeken_US
dc.contributor.authorKooruethai Phra-Eken_US
dc.contributor.authorLaurent Réniaen_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorChakrit Hirunpetcharaten_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorAlan Brockmanen_US
dc.contributor.authorAnne Charlotte Grüneren_US
dc.contributor.authorNicolas Lebrunen_US
dc.contributor.authorAli Allouecheen_US
dc.contributor.authorFrançois Nostenen_US
dc.contributor.authorSrisin Khusmithen_US
dc.contributor.authorGeorges Snounouen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherUniversite Paris Descartesen_US
dc.contributor.otherChurchill Hospitalen_US
dc.contributor.otherNovartis Immunobiological Research Instituteen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherMuseum National d'Histoire Naturelleen_US
dc.contributor.otherCNRS Centre National de la Recherche Scientifiqueen_US
dc.identifier.citationJournal of Immunology. Vol.175, No.6 (2005), 3935-3939en_US
dc.description.abstractProtective cellular immune responses depend on MHC presentation of pathogen-derived Ag fragments. MHC diversity renders this process sensitive to point mutations coding for altered amino acid sequence of the short target Ag-derived peptides epitopes. Thus, in a given host, a pathogen with an altered epitope sequence will be more likely to escape detection and elimination by the immune system. At a population level, selection by immune pressure will increase the likelihood of polymorphism in important pathogen antigenic epitopes. This mechanism of immune evasion is found in viruses and other pathogens. The detection of polymorphic hot spots in an Ag is often taken as a strong indication of its role in protective immunity. We provide evidence that polymorphisms in the T cell epitopes of a malaria vaccine candidate are unlikely to have been selected by immune pressure in the human host. Copyright © 2005 by The American Association of Immunologists, Inc.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAre extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressureen_US
Appears in Collections:Scopus 2001-2005

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