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Title: Schistosoma mekongi: A prominent neutrophil chemotactic activity of egg antigen with reference to that of Schistosoma japonicum
Authors: Makoto Owhashi
Jun Matsumoto
Atsuko Imase
Masashi Kirinoki
Viroj Kitikoon
Yuichi Chigusa
Hajime Matsuda
Tokushima University
Dokkyo University
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-2005
Citation: Experimental Parasitology. Vol.110, No.4 (2005), 335-341
Abstract: Schistosoma mekongi causes granulomatous lesions around eggs deposited in the liver with neutrophil-rich inflammatory reactions in the early stage of the egg laying. To define the aspects of the typical pathogenesis of S. mekongi infection, we determined the difference between soluble egg antigen (SEA) from S. mekongi and S. japonicum with a focus on chemotactic factors for neutrophils or eosinophils. Mean volume and protein amount of S. mekongi eggs was 71 and 58% of those of Schistosoma japonicum eggs, respectively. Neutrophil chemotactic activity of S. mekongi SEA was about two times higher than that of S. japonicum. In contrast, eosinophil chemotactic activity of S. mekongi SEA was about half of that of S. japonicum SEA. Molecular analysis revealed that S. mekongi SEA contains higher molecular-weight components with a lower level of glycosylation, and this is likely to be related to the intense neutrophil chemotactic activity in comparison with S. japonicum SEA. The prominent chemotactic reactivity for neutrophils is likely to be involved in the typical pathogenesis of mekongi schistosomiasis. © 2005 Elsevier Inc. All rights reserved.
ISSN: 00144894
Appears in Collections:Scopus 2001-2005

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