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dc.contributor.authorIsabelle M. Medanaen_US
dc.contributor.authorRalf Björn Linderten_US
dc.contributor.authorUlrich Wursteren_US
dc.contributor.authorTran Tinh Hienen_US
dc.contributor.authorNicholas P.J. Dayen_US
dc.contributor.authorNguyen Hoan Phuen_US
dc.contributor.authorNguyen Thi Hoang Maien_US
dc.contributor.authorLy Van Chuongen_US
dc.contributor.authorTran Thi Hong Chauen_US
dc.contributor.authorGareth D.H. Turneren_US
dc.contributor.authorJeremy J. Farraren_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherMedizinische Hochschule Hannover (MHH)en_US
dc.contributor.otherOxford University Clinical Research Uniten_US
dc.contributor.otherChurchill Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. Vol.99, No.8 (2005), 610-617en_US
dc.description.abstractA retrospective study of cerebrospinal fluid (CSF) markers of brain parenchymal damage was conducted in Vietnamese adults with severe malaria. Three markers were analysed by immunoassays: the microtubule-associated protein tau, for degenerated axons; neuron-specific enolase (NSE), for neurons; and S100B for astrocytes. The mean concentration of tau proteins in the CSF was significantly raised in patients with severe malaria compared with controls (P = 0.0003) as reported for other central nervous system diseases. By contrast, the mean concentration of NSE and S100B remained within the normal range. Tau levels were associated with duration of coma (P = 0.004) and S100B was associated with convulsions (P = 0.006). Concentrations of axonal and astrocyte degeneration markers also were associated with vital organ dysfunction. No association was found between the level of markers of brain parenchymal damage on admission and a fatal outcome. On admission to hospital, patients with severe malaria had biochemical evidence of brain parenchymal damage predominantly affecting axons. © 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleCerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malariaen_US
Appears in Collections:Scopus 2001-2005

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