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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/16585
Title: Immunohistological characterization of macrophage migration inhibitory factor expression in Plasmodium falciparum-infected placentas
Authors: Sujittra Chaisavaneeyakorn
Naomi Lucchi
Carlos Abramowsky
Caroline Othoro
Sansanee C. Chaiyaroj
Ya Ping Shi
Bernard L. Nahlen
David S. Peterson
Julie M. Moore
Venkatachalam Udhayakumar
National Center for Infectious Diseases
The University of Georgia
Emory University School of Medicine
Kenya Medical Research Institute
Atlanta Research and Education Foundation
Mahidol University
Organisation Mondiale de la Sante
Centers for Disease Control and Prevention
Keywords: Immunology and Microbiology
Issue Date: 1-Jun-2005
Citation: Infection and Immunity. Vol.73, No.6 (2005), 3287-3293
Abstract: Previously, we have shown that macrophage migration inhibitory factor (MIF) was highly elevated in the placental intervillous blood (IVB) of Plasmodium falciparum-infected women. Here, we compared the expression of MIF in placental tissues obtained from P. falciparum-infected and -uninfected women. Immunoperoxidase staining showed a consistent pattern of MIF expression in syncytiotrophoblasts, extravillous trophoblasts, IVB mononuclear cells, and amniotic epithelial cells, irrespective of their malaria infection status. Cytotrophoblast, villous stroma, and Hofbauer cells showed focal staining. Only amniotic epithelial and IVB mononuclear cells from P. falciparum-infected placentas exhibited significantly higher level of MIF expression than uninfected placentas. Stimulation of syncytilized human trophoblast BeWo cells with P. falciparum-infected erythrocytes that were selected to bind these cells resulted in significant increases in MIF secretion, whereas control erythrocytes, lipopolysaccharides, and synthetic β-hematin had minimal effect. These findings suggest that placental malaria modulates MIF expression in different placental compartments. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=21144478619&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/16585
ISSN: 00199567
Appears in Collections:Scopus 2001-2005

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