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Title: Identification and preliminary characterization of cell-wall-anchored proteins of Staphylococcus epidermidis
Authors: M. Gabriela Bowden
Wei Chen
Jenny Singvall
Yi Xu
Sharon J. Peacock
Viviana Valtulina
Pietro Speziale
Magnus Höök
Texas A and M University
Mahidol University
Universita degli Studi di Pavia
Keywords: Immunology and Microbiology
Issue Date: 1-May-2005
Citation: Microbiology. Vol.151, No.5 (2005), 1453-1464
Abstract: Staphylococcus epidermidis is a ubiquitous human skin commensal that has emerged as a major cause of foreign-body infections. Eleven genes encoding putative cell-wall-anchored proteins were identified by computer analysis of the publicly available S. epidermidis unfinished genomic sequence. Four genes encode previously described proteins (Aap, Bhp, SdrF and SdrG), while the remaining seven have not been characterized. Analysis of primary sequences of the Staphylococcus epidermidis surface (Ses) proteins indicates that they have a structural organization similar to the previously described cell-wall-anchored proteins from S. aureus and other Gram-positive cocci. However, not all of the Ses proteins are direct homologues of the S. aureus proteins. Secondary and tertiary structure predictions suggest that most of the Ses proteins are composed of several contiguous subdomains, and that the majority of these predicted subdomains are folded into β-rich structures. PCR analysis indicates that certain genes may be found more frequently in disease isolates compared to strains isolated from healthy skin. Patients recovering from S. epidermidis infections had higher antibody titres against some Ses proteins, implying that these proteins are expressed during human infection. Western blot analyses of early-logarithmic and late-stationary in vitro cultures suggest that different regulatory mechanisms control the expression of the Ses proteins. © 2005 SGM.
ISSN: 13500872
Appears in Collections:Scopus 2001-2005

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