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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/16620
Title: Burkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis
Authors: Allen C. Cheng
Nicholas P.J. Day
Mark J. Mayo
Daniel Gal
Bart J. Currie
Menzies School of Health Research
Flinders University
University of Oxford
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2005
Citation: Microbes and Infection. Vol.7, No.1 (2005), 104-109
Abstract: Melioidosis, the infection due to Burkholderia pseudomallei, may present with a spectrum of severity and may affect any site in the body. Differential strain virulence and tropism suggested by previous studies would have implications for virulence and vaccine work. We explored clinical correlations using pulsed-field gel electrophoresis (PFGE) typing in a well-characterised clinical collection. Two methods of analysis were used based on band-based similarity values: first, a conventional cluster analysis formed by the unweighted paired group mean analysis, and second, an analysis of the distribution of the "within-group" and "between-group" Dice coefficient. Clinical isolates from 114 cases of melioidosis occurring in the Northern Territory, Australia were studied; 71 strain types were defined with a Simpson's index of 0.91. No correlation was found between strain type and disease severity or site of melioidosis on presentation, with no differences in similarity values found when comparing within and between-groups. In particular, isolates from patients with neurological melioidosis were not clustered. There was evidence of geographical localisation. This study suggests that the variation in strain type may not be as important as host and environmental factors in determining the pattern of disease. © 2004 Elsevier SAS. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=15944416700&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/16620
ISSN: 12864579
Appears in Collections:Scopus 2001-2005

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