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Title: Comparison of physiological, cytopathogenic and immunological properties between two environmental isolates of Acanthamoeba spp.
Authors: Duangporn Nacapunchai
Chongrak Permmongkol
Sompong Sripochang
Bangourn Sermsart
Thongdee Suvajeejarun
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2005
Citation: The Southeast Asian journal of tropical medicine and public health.. Vol.36 Suppl 4, (2005), 1-4
Abstract: The aim of this study was to determine whether pathogenic and less-pathogenic isolates of environmental Acanthamoeba exhibit differences in adhesion to human erythrocytes. Based on physiological properties of temperature, tolerance, and rapid growth, Acanthamoeba were divided into pathogenic and less-pathogenic isolates. Acanthamoeba were tested for their ability to produce cytopathic effects (CPE) using two human cell lines, HEp-2 and KB cells. Both ameba isolates caused CPE to both cell lines with the same pattern without significant difference. Human erythrocytes from 20 healthy volunteers were used to study the erythrocyte reactivity of Acanthamoeba by co-incubation with trophozoites. The pathogenic Acanthamoeba exhibited significantly higher erythrocyte adhesion as compared to the less-pathogens (p<0.05). Erythrocyte activity occurred in the presence of plasma in all blood samples, suggesting the role of plasmatic components and contact-dependent mechanisms to produce host cell cytotoxicity. The present results showed correlation between the physiological properties and erythrocyte reactivity of Acanthamoeba.
ISSN: 01251562
Appears in Collections:Scopus 2001-2005

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