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dc.contributor.authorCecilia Perreten_US
dc.contributor.authorPornthep Chanthavanichen_US
dc.contributor.authorKrisana Pengsaaen_US
dc.contributor.authorKriengsak Limkittikulen_US
dc.contributor.authorPornsom Hutajaroenen_US
dc.contributor.authorJames E.G. Bunnen_US
dc.contributor.authorBernard J. Brabinen_US
dc.contributor.otherPontificia Universidad Catolica de Chileen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherLiverpool School of Tropical Medicineen_US
dc.contributor.otherEmma Kinderziekenhuisen_US
dc.contributor.otherRajvithee Hospitalen_US
dc.identifier.citationJournal of Infection. Vol.51, No.4 (2005), 287-293en_US
dc.description.abstractObjectives. The objectives of this study were to estimate dengue seroprevalence in a population of Thai pregnant women, living in a highly endemic area and placental transfer of dengue antibodies. Methods. A cross-sectional seroprevalence study of 245 pregnant women at delivery. Results. Dengue HAI antibodies were positive in 94.7%. Maternal age was the only risk factor associated with dengue infection as older mothers (>20 years) were significantly more likely to be seropositive than younger women (p<0.0001). Cord antibody titres varied with maternal age and antibody titre, were significantly higher in babies born to younger mothers (<20 years) (p=0.01), and were significantly correlated with maternal titre. Low birthweight babies had lower transfer ratios for DEN-2 antibody (1.06) compared to heavier babies (1.36, p=0.05). No mother or neonate had dengue IgM detected. Two women were classified as recently, but not currently infected with dengue virus and we consider it likely these were first trimester infections. As no infant became infected the fetal infection was 0%. Conclusions. Younger mothers were more likely to have been recently infected, resulting in higher antibody titres. Maternal dengue antibody transfer was proportional to maternal antibody concentration. © 2004 The British Infection Society. Published by Elsevier Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.titleDengue infection during pregnancy and transplacental antibody transfer in Thai mothersen_US
Appears in Collections:Scopus 2001-2005

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