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Title: Relationship between hyperhomocysteinemia and atherosclerosis in chronic hemodialysis patients
Authors: Puntapong Taruangsri
Leena Ong-Ajyooth
Sompong Ong-Ajyooth
Walailak Chaiyasoot
Wattana Leowattana
Suchai Sritippayawan
Kriengsak Vareesangthip
Thawee Chanchairujira
Somkiat Vasuvattakul
Chairat Shayakul
Supat Vanichakarn
Mahidol University
Keywords: Medicine
Issue Date: 1-Oct-2005
Citation: Journal of the Medical Association of Thailand. Vol.88, No.10 (2005), 1373-1381
Abstract: Background: Hyperhomocysteinemia is an independent risk factor of coronary artery heart disease (CAHD) and atherosclerosis in a normal population. However, it is still controversial in end-stage kidney disease patients who underwent long-term dialysis. Carotid intima-media thickness (IMT) is the standard non-invasive measurement of atherosclerosis. The aims of the present study were to determine the homocysteine (Hcy) level, and to evaluate its role as a risk factor of atherosclerosis in hemodialysis (HD) patients. Material and Method: Clinical data and blood chemistries were assayed in 62 HD patients. Atherosclerosis was defined by clinical presentations of CAHD, cerebrovascular or peripheral vascular diseases, or carotid plaque by ultrasound. IMT was also measured by ultrasound. Results: Plasma Hcy level in HD patients was significantly higher in HD patients than normal controls (28.3 8.3 vs 9.7 2.9 μmol/l, p < 0.001). Older age (p < 0.001), male sex (p = 0.05), longer duration of HD (p = 0.05), and higher plasma Hcy level (p = 0.01) correlated with atherosclerosis by univariate analysis, but plasma Hcy did not show significant correlation by multivariable analysis. There was also correlation between IMT and atherosclerosis in HD patients (p < 0.001) but no correlation was observed between plasma Hcy level and IMT. Conclusion: Hyperhomocysteinemia is not an independent factor in the genesis of atherosclerosis in HD patients. Advanced age plays a major role of hyperhomocysteinemia and IMT is a useful marker of atherosclerosis in these patients.
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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