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Title: Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand
Authors: Mallika Imwong
Sasithon Pukrittayakamee
Qin Cheng
Catrin Moore
Sornchai Looareesuwan
Georges Snounou
Nicholas J. White
Nicholas P.J. Day
Mahidol University
Australian Army Malaria Institute
Churchill Hospital
Institut Pasteur, Paris
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2005
Citation: Antimicrobial Agents and Chemotherapy. Vol.49, No.10 (2005), 4393-4395
Abstract: The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of P\dhps and P\dhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
ISSN: 00664804
Appears in Collections:Scopus 2001-2005

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