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dc.contributor.authorRuangyuth Chaiworapornen_US
dc.contributor.authorYaowapa Maneeraten_US
dc.contributor.authorWichit Rojekittikhunen_US
dc.contributor.authorPongrama Ramasootaen_US
dc.contributor.authorTuenta Janecharuten_US
dc.contributor.authorHajime Matsudaen_US
dc.contributor.authorViroj Kitikoonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherSilpakorn Universityen_US
dc.contributor.otherDokkyo Medical Universityen_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.5 (2005), 1118-1124en_US
dc.description.abstractThe effect of artesunate (ART) on the pathology and mortality rate of in Schistosoma mansoni infected mice was comparatively studied with the current drugs of choice for the treatment of schistosomiasis mansoni: praziquantel (PZQ) and oxamniquine (OX). S. mansoni experimentally infected mice were treated at 9 th week of infection with ART, PZQ or OX at an oral dosage of 300 mg kg -1, 600 mg kg -1 and 100 mg kg -1, respectively. Untreated, infected mice and non-infected mice were added as controls. Samples of mice were sacrificed and examined for the pathological findings at 1 week, 1 month, and 3 months after treatment. At 1 week after treatment, both gross and microscopic lesions were observed. No significant differences were noted among the infected groups. Differences were observed at 1 month after treatment. The lesions decreased more rapidly in groups treated with PZQ and OX. At 3 months after treatment, there were significant differences in the pathological findings among groups. In the groups treated with PZQ and OX, the lesions were markedly reduced and rarely found, but they were clearly observed in the group treated with ART and in the untreated, infected group. High mortality was also recorded in the group treated with ART and in the untreated, infected group. Therefore, the treatment of S. mansoni infected mice at 9 weeks of infection with ART did not reduce the pathological findings or the mortality rate compared to treatment with the current recommended schistosomicides, PZQ and OX.en_US
dc.rightsMahidol Universityen_US
dc.titleComparative studies on the pathological findings and mortality in Schistosoma mansoni infected mice after treatment with artesunate and the current antischistosomal drugsen_US
Appears in Collections:Scopus 2001-2005

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