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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/16891
Title: Chronic rhinosinusitis and recurrent nasal polyps in two children with IgG subclass deficiency and review of the literature
Authors: Sasawan Chinratanapisit
Prayuth Tunsuriyawong
Pakit Vichyanond
Nualanong Visitsunthorn
Voravich Luangwedchakarn
Orathai Jirapongsananuruk
Mahidol University
Keywords: Medicine
Issue Date: 1-Aug-2005
Citation: Journal of the Medical Association of Thailand. Vol.88, No.SUPPL. 8 (2005)
Abstract: Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of mucosa of the nose and the paranasal sinuses. Two major forms of CRS can be differentiated; CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). The pathophysiology and etiology of nasal polyps (NPs) are partly understood. IgG subclass deficiency was shown to be associated with an increased susceptibility to infections. However, the association between NPs and IgG subclass deficiency has never been reported. Objectives: To report two cases of recalcitrant CRS and recurrent NPs with IgG subclass deficiency. Case report: Two children (6 and 8 year-old boys) were referred to the Pediatric Allergy/Immunology Clinic, Siriraj Hospital due to a prolonged history of CRS and recurrent NPs. Both of them were treated with aggressive medical (topical and systemic corticosteroids, antibiotics, leukotriene antagonist, nasal irrigation) as well as surgical therapy, without significant improvement. Immunologic investigation in both patients showed that IgG, IgA, and IgM level were normal. IgG subclasses level in patient No. 1 were IgG1 1,235 (280-1120) mg/dl (79%), IgG2 235 (30-630) mg/dl (23.5%), IgG3 27.3 (40-250) mg/dl (1.74%), and IgG4 92.4 (11-620) mg/dl (5.9%). IgG subclasses level in patient No. 2 were IgG1 1,139 (280-1120) mg/dl (82.5%), IgG2 170 (30-630) mg/dl (12.3%), IgG3 5.6 (40-250) mg/dl (0.4%), IgG4 65.7 (11-620) mg/dl (4.8%). The diagnosis of CRS and recurrent NPs with IgG3 subclass deficiency in the first patient and IgG2/IgG3 subclass deficiency in the second patient were made. Patient No. 1 was given monthly IVIG therapy for the total of 7 courses and medications were gradually tapered. Currently, the patient is doing well after the cessation of IVIG therapy for 3 months. Patient No. 2 denied the IVIG treatment and was lost to follow up. Conclusion: We reported two cases of recalcitrant CRS and recurrent NPs in children. Immunologic work up revealed IgG subclass deficiency. The treatment with monthly IVIG improved CRS and NPs in treated patient which brought up the possibility of association between NPs and IgG subclass deficiency. Further study on the direct role of IVIG in NPs will be needed in the future.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=31744435649&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/16891
ISSN: 01252208
01252208
Appears in Collections:Scopus 2001-2005

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