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Title: Systematic review and meta-analysis of the association between β<inf>2</inf>-adrenoceptor polymorphisms and asthma: A HuGE review
Authors: Ammarin Thakkinstian
Mark McEvoy
Cosetta Minelli
Peter Gibson
Bob Hancox
David Duffy
John Thompson
Ian Hall
Joel Kaufman
Ting Fan Leung
Peter Joseph Helms
Hakon Hakonarson
Eva Halpi
Ruth Navon
John Attia
Mahidol University
University of Newcastle, Australia
University of Leicester
John Hunter Hospital
Waikato Hospital
Queensland Institute of Medical Research
Nottingham University Hospitals NHS Trust
University of Washington School of Public Health and Community Medicine
Chinese University of Hong Kong
University of Aberdeen School of Medicine
deCODE genetics
Tel Aviv University, Sackler Faculty of Medicine
Keywords: Medicine
Issue Date: 1-Aug-2005
Citation: American Journal of Epidemiology. Vol.162, No.3 (2005), 201-211
Abstract: A number of studies have investigated two common polymorphisms in the β2-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of these two polymorphic sites, the linkage disequilibrium coefficient of 0.41 was not high (p < 0.001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16. Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
ISSN: 00029262
Appears in Collections:Scopus 2001-2005

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