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Title: Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei
Authors: Vanaporn Wuthiekanun
Allen C. Cheng
Wirongrong Chierakul
Premjit Amornchai
Direk Limmathurotsakul
Wipada Chaowagul
Andrew J.H. Simpson
Jennifer M. Short
Gumphol Wongsuvan
Bina Maharjan
Nicholas J. White
Sharon J. Peacock
Mahidol University
Menzies School of Health Research
Sappasitthiprasong Hospital
Heartlands Hospital
Nuffield Department of Clinical Medicine
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2005
Citation: Journal of Antimicrobial Chemotherapy. Vol.55, No.6 (2005), 1029-1031
Abstract: Objectives: Trimethoprim/sulfamethoxazole is commonly used to treat melioidosis. Antimicrobial susceptibility testing using the disc diffusion method is commonly used in melioidosis-endemic areas, but may overestimate resistance to trimethoprim/sulfamethoxazole. Patients and methods: We performed disc diffusion and Etest on isolates from the first positive culture for all patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with culture-confirmed melioidosis between 1992 and 2003. Results: The estimated resistance rate for 1976 clinical Burkholderia pseudomallei isolates was 13% by Etest and 71% by disc diffusion. All isolates classed as either susceptible (n=358) or as having intermediate resistance (n=218) on disc diffusion were susceptible by Etest. Only 258 of the 1400 (18%) isolates classed as resistant on disc diffusion were resistant by Etest. Conclusions: Disc diffusion testing of B. pseudomallei may be useful as a limited screening tool in resource poor settings. Isolates assigned as 'susceptible' or 'intermediate' by disc diffusion may be viewed as 'susceptible'; those assigned as 'resistant' require further evaluation by MIC methodology. © The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
ISSN: 03057453
Appears in Collections:Scopus 2001-2005

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