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Title: Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
Authors: Nottasorn Plipat
Gilat Livni
Heidi Bertram
Richard B. Thomson
Mahidol University
Schneider Childrens Medical Center Israel
Department of Pathology and Laboratory Medicine
Northwestern University Feinberg School of Medicine
Keywords: Medicine
Issue Date: 1-May-2005
Citation: Journal of Clinical Microbiology. Vol.43, No.5 (2005), 2494-2496
Abstract: We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
ISSN: 00951137
Appears in Collections:Scopus 2001-2005

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