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dc.contributor.authorKrisana Pengsaaen_US
dc.contributor.authorChukiat Sirivichayakulen_US
dc.contributor.authorKesara Na-Bangchangen_US
dc.contributor.authorItthipon Thaiarpornen_US
dc.contributor.authorAnong Chaivisuthen_US
dc.contributor.authorAmnaj Wongsuwanen_US
dc.contributor.authorPhanorsri Attanathen_US
dc.contributor.authorChanathep Pojjaroen-Ananten_US
dc.contributor.authorPataraporn Wisetsingen_US
dc.contributor.authorPornthep Chanthavanichen_US
dc.contributor.authorArunee Sabchareonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThammasat Universityen_US
dc.contributor.otherThong Pha Phum Hospitalen_US
dc.contributor.otherPaholpolpayuhasena Hospitalen_US
dc.contributor.otherMae Sot General Hospitalen_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.3 (2005), 597-601en_US
dc.description.abstractWe report the effectiveness of two regimens of rectal artesunate formulation in treating 13 Thai children with cerebral/complicated falciparum malaria. The drug was given at an initial dose of 40 mg/kg bodyweight, in 3 or 4 divided doses in the first 24 hours, followed by 10 mg/kg bodyweight once daily for three consecutive days. Mefloquine, at a dose of 15 mg/kg bodyweight was given orally at 72 hours after the initial dose of artesunate, followed by 10 mg/kg bodyweight 6 hours later. Three cases with cerebral malaria gained consciousness within 20 hours of artesunate administration. The median time required for reduction of parasitemia by 90% of the initial value (P 90) in 13 children was 11.2 hours. No recrudescence was observed in any of the patients during the 28-day follow-up period. Plasma concentrations of artesunate and dihydroartemisinin (active plasma metabolite of artesunate) measured in two patients who received the high initial dose regimen (20 mg/ kg bodyweight) suggested rapid absorption and adequate plasma concentrations of both compounds following the administration of artesunate via the rectal route. Further studies for the optimized regimen of rectal artesunate in the treatment of cerebral/complicated childhood falciparum malaria in areas of multidrug resistance are warranted.en_US
dc.rightsMahidol Universityen_US
dc.titleLife-saving rectal artesunate for complicated malaria in childrenen_US
Appears in Collections:Scopus 2001-2005

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