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Title: Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents
Authors: Paul M. Coplan
Swati B. Gupta
Sheri A. Dubey
Punnee Pitisuttithum
Alex Nikas
Bernard Mbewe
Efthyia Vardas
Mauro Schechter
Esper G. Kallas
Dan C. Freed
Tong Ming Fu
Christopher T. Mast
Pilaipan Puthavathana
James Kublin
Kelly Brown Collins
John Chisi
Richard Pendame
Scott J. Thaler
Glenda Gray
James Mcintyre
Walter L. Straus
Jon H. Condra
Devan V. Mehrotra
Harry A. Guess
Emilio A. Emini
John W. Shiver
Merck Research Laboratories
Mahidol University
Malawi College of Medicine
Ministry of Population and Health
Universidade Federal do Rio de Janeiro
Universidade Federal de Sao Paulo
University of Witwatersrand
Intl. Partnership for Microbicides
The University of North Carolina at Chapel Hill
International AIDS Vaccine Initiative
International Partnership for Microbicides
Keywords: Medicine
Issue Date: 1-May-2005
Citation: Journal of Infectious Diseases. Vol.191, No.9 (2005), 1427-1434
Abstract: Background. The genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti-HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades. Methods. Cellular immune responses to HIV-1 clades A, B, and C were compared by standardized interferon-γ enzyme-linked immunospot assays among 250 unvaccinated individuals, infected with diverse HIV-1 clades, from Brazil, Malawi, South Africa, Thailand, and the United States. Cross-clade reactivity was evaluated by use of the ratio of responses to heterologous versus homologous (infecting) clades of HIV-1. Results. Cellular immune responses were predominantly focused on viral Gag and Nef proteins. Cross-clade reactivity of cellular immune responses to HIV-1 clade A, B, and C proteins was substantial for Nef proteins (ratio, 0.97 [95% confidence interval, 0.89-1.05]) and lower for Gag proteins (ratio, 0.67 [95% confidence interval, 0.62-0.73]). The difference in cross-clade reactivity to Nef and Gag proteins was significant (P < .0001). Conclusions. Cross-clade reactivity of cellular immune responses can be substantial but varies by viral protein. © 2005 by the Infectious Diseases Society of America. All rights reserved.
ISSN: 00221899
Appears in Collections:Scopus 2001-2005

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