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Title: A prospective, randomized double-blind study in children comparing two doses of nebulized L-epinephrine in postintubation croup
Authors: Aroonwan Preutthipan
Preamrudee Poomthavorn
Apinya Sumanapisan
Benchaporn Chinrat
Sriwanna Thasuntia
Adisak Plitponkarnpim
Teerachai Chantarojanasiri
Mahidol University
Keywords: Medicine
Issue Date: 1-Apr-2005
Citation: Journal of the Medical Association of Thailand. Vol.88, No.4 (2005), 508-512
Abstract: Objective: To compare the effectiveness and side effects of nebulized l-epinephrine (NLE) at a dose of 0.05 mL/kg versus 0.5 mL/kg in the treatment of postintubation croup in children. Material and Method: Thirty-nine children, who developed signs and symptoms of upper airway obstruction (UAO) after extubation, were randomized to receive either 0.05 mL/kg or 0.5 mL/kg of NLE. UAO scores, vital signs (VS) and possible side effects were recorded before and at 20 and 40 minutes after the treatment. Results: Twenty-one and 18 patients were allocated to the 0.05 and 0.5 mL/kg groups, respectively. Both groups showed improvements in UAO scores over time. There were no significant differences in UAO scores and VS between the groups at all time points. Side effects of epinephrine were not observed. Conclusion: In children with postintubation croup, the administration of NLE at the dose of 0.05 mL/kg results in similar improvements in the UAO scores, compared with the dose of 0.5 mL/kg. No complications were seen in either dose.
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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