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|Title:||Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese thais|
Frank Peter Schelp
Freie Universitat Berlin
|Citation:||Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.2 (2005), 459-466|
|Abstract:||We analyzed the association between MTHFR (C677T) gene polymorphism with serum concentrations of homocysteine, folate, and vitamin B12in 37 male and 112 female overweight/obese Thai volunteers (BMI ≥25.00 kg/m2), and compared them with 23 male and 90 female control subjects (BMI=18.5-24.99 kg/m2). Statistically significant higher levels of serum homocysteine were found in the overweight/obese subjects than the control subjects (p<0.05). Serum folic acid levels in the overweight/obese subjects were significantly lower than the control subjects (p< 0.05). When the data were grouped according to homocysteine concentration and MTHFR gene polymorphism, there were significantly higher homocysteine concentrations in the overweight/obese subjects than the control subjects in wild type gene polymorphism (CC) in the hyperhomocysteine group (homocysteine >10.0 mmol/l) (p<0.05), but in genotype polymorphism (CC, CT, TT) there were lower folic acid and vitamin B12concentrations in the overweight/obese subjects than in the control subjects. In the hyperhomocysteine groups, there was no significant difference in the frequencies of MTHFR (C677T) gene polymorphism between the overweight/obese subjects and the control subjects. Folic acid and gene polymorphism were found to be significantly related to the overweight/obese and control groups in logistic regression analysis (p<0.05). The results support the supposition that folic acid is more important than vitamin B12.|
|Appears in Collections:||Scopus 2001-2005|
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