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Title: The efficacy of anti-malaria drugs against Plasmodium vivax on the Thailand-Myanmar border
Authors: Takeshi Yoda
Yasuyuki Rakue
Tsutomu Mizota
Sornchai Looareesuwan
Nagasaki University
Toda Central General Hospital
Tulane University
Mahidol University
Keywords: Medicine
Issue Date: 1-Mar-2005
Citation: Journal of Tokyo Medical University. Vol.63, No.2 (2005), 140-143
Abstract: The susceptibility of 20 isolates of Plasmodium vivax obtained in the area of the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC 50) values were quinine=308 ng/ml, amodiaquine=14 ng/ml, chloroquine=50 ng/ml, mefloquine=127 ng/ml, sulfadoxine/pyrimethamine (80:1) =800/10 ng/ml, pyrimethamine=8 ng/ml, and artesunate=0.5 ng/ml. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.
ISSN: 00408905
Appears in Collections:Scopus 2001-2005

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