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dc.contributor.authorWitthawat Wiriyaraten_US
dc.contributor.authorSanya Sukpanichnanten_US
dc.contributor.authorNopporn Sittisombuten_US
dc.contributor.authorKruavon Balanchandraen_US
dc.contributor.authorDuanthanorm Promkhatkaewen_US
dc.contributor.authorRaywadee Butrapornen_US
dc.contributor.authorRuengpung Sutthenten_US
dc.contributor.authorJotika Boonlongen_US
dc.contributor.authorKazuhiro Matsuoen_US
dc.contributor.authorMitsuo Hondaen_US
dc.contributor.authorPaijit Warachiten_US
dc.contributor.authorPilaipan Puthavathanaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherJapan Science and Technology Agencyen_US
dc.contributor.otherNational Institute of Infectious Diseasesen_US
dc.identifier.citationAsian Pacific Journal of Allergy and Immunology. Vol.23, No.1 (2005), 41-51en_US
dc.description.abstractRecombinant BCGs (rBCGs) containing extrachromosomal plasmids with different HIV-1 insert sequences: nef, env (V3J1 and E9Q), gag p17 or whole gag p55 were evaluated for their immunogenicity, safety and persistent infection in BALB/c mice. Animal injected with, rBCG-pIJKV3J1, rBCG-pSO gag p17 or rBCG-pSO gag p55 could elicit lymphocyte proliferation as tested by specific HIV-1 peptides or protein antigen. Inoculation with various concentration of rBCG-pSO gag p55 generated satisfactory specific lymphocyte proliferation in dose escalation trials. The rBCG-pSO gag p55 recovered from spleen tissues at different time interval post-inoculation could express the HIV protein as determined by ELISA p24 antigen detection kit. This result indicated that the extrachromosomal plasmid was stable and capable to express Gag protein. It was also demonstrated that rBCGs did not cause serious pathological change in the inoculated animals. The present study suggested the role of BCG as a potential vehicle for using in HIV vaccine development.en_US
dc.rightsMahidol Universityen_US
dc.titleSpecific immune response and pathological findings in BALB/c mice inoculated with recombinat BCG expressing HIV-1 antigenen_US
Appears in Collections:Scopus 2001-2005

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