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Title: Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes
Authors: Jitra Waikagul
Dorn Watthanakulpanich
Chatree Muennoo
Wanna Maipanich
Surapol Sa-Nguankiat
Somchit Phubampen
Mahidol University
Keywords: Medicine
Issue Date: 1-Feb-2005
Citation: Journal of the Medical Association of Thailand. Vol.88, No.2 (2005), 233-237
Abstract: The efficacy of a single dose of benzimidazole, drugs commonly used for the treatment of Ascaris and hookworm, was evaluated against one of the tiny-sized intestinal flukes, Haplorchis sp in the endemic area where mixed infections of roundworms and flatworms existed. At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40mg/kg) gave 94.6% cure rate and the placebo at 15.9%. At the single dose, benzimidazole could not completely expelled the haplorchid; but could reduce one third to two fifth of the infection, similar to the drugs efficacy against Trichuris infection.
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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