Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/1714
Title: Anthelminthic effects of artemisinin and its derivatives
Other Titles: ประสิทธิภาพของอาติมิซินินและสารอนุพันธ์ในการใช้เป็นยาถ่ายพยาธิ
Authors: Tawewan Tansatit
Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal Science
Keywords: artemisinin;artesunate;artemether;anthelminthic;อาติมิซินิน;อาทีซูเนต;อาทีมิเทอร์;ยาถ่ายพยาธิ;Open Access article
Issue Date: 2013
Citation: Journal of Applied Animal Science. Vol.6, No.1 (Jan-Apr 2013), 17-26
Abstract: Qinghao (Artemisia annua, L.), a famous herb from China, has been used in traditional Chinese medicine. Artemisinin, an active substance is extracted from the leaves and flowers of Qinghao, with a unique sesquiterpene lactone endoperoxide structure showing an antimalarial activity. Derivatives of artemisinin, artesunate and artemether, are the most widely used as antimalarial drugs. Since artemisinin not only possess antimalarial properties, but also active against various parasitic infection. Ongoing research on these compounds has been emphasized on the potential impact for anthelmintic treatment. Artemisinin derivatives exhibited a broad spectrum property against various trematodes, nematode, and cestode both in vitro and in vivo studies. These helminthocidal properties of artemisinin derivatives presented here provide further data for clinical investigations in the field trial study. However, a better understanding of action of artemisinin derivatives and their biomolecule target may contribute a promising possibility for clinical utility in anthelmintic application. Toxicity of artemisinin derivatives was less and was demonstrated in experimental animals with neurotoxicity and anemia.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/1714
ISSN: 1906-2257
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