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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/17163
Title: Environmental and occupational exposure to benzene in Thailand
Authors: Panida Navasumrit
Sirirat Chanvaivit
Pornpat Intarasunanont
Manaswee Arayasiri
Narumon Lauhareungpanya
Varaporn Parnlob
Daam Settachan
Mathuros Ruchirawat
Chulabhorn Research Institute
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 30-May-2005
Citation: Chemico-Biological Interactions. Vol.153-154, (2005), 75-83
Abstract: Exposure to benzene in air is a concern in Thailand, particularly since it was observed that the incidence of blood-related cancers, such as leukemia and lymphoma, has increased in the past few decades. In Bangkok, the mean atmospheric levels of benzene on main roads and in schools were 33.71 and 8.25 ppb, respectively, while in gasoline service stations and petrochemical factories the mean ambient levels were 64.78 and 66.24 ppb, respectively. Cloth vendors (22.61 ppb) and grilled-meat vendors (28.19 ppb) working on the roadsides were exposed to significantly higher levels of benzene than the control group (12.95 ppb; p < 0.05). Bangkok school children (5.50 ppb) were exposed to significantly higher levels of benzene than provincial school children (2.54 ppb; p < 0.01). Factory workers (73.55 ppb) and gasoline service attendants (121.67 ppb) were exposed to significantly higher levels of benzene than control workers (4.77 ppb; p < 0.001). In accordance with the increased benzene exposures, levels of urinary trans,trans-muconic acid (MA) were significantly increased in all benzene-exposed groups. In school children, the levels of MA were relatively high, taking into account the much lower level of exposure. Blood benzene levels were also significantly increased in Bangkok school children (77.97 ppt; p < 0.01), gasoline service attendants (641.84 ppt; p < 0.05) and factory workers (572.61 ppt; p < 0.001), when compared with the respective controls. DNA damage, determined as DNA strand breaks, was found to be elevated in gasoline service attendants, petrochemical factory workers, and Bangkok school children (p < 0.001). The cytogenetic challenge assay, which measures DNA repair capacity, showed varying levels of significant increases in the numbers of dicentrics and deletions in gasoline service attendants, petrochemical factory workers and Bangkok school children, indicating a decrease in DNA repair capacity in these subjects. © 2005 Elsevier Ireland Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=20444365784&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/17163
ISSN: 00092797
Appears in Collections:Scopus 2001-2005

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