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Title: Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells
Authors: Kriengsak Lirdprapamongkol
Hiroaki Sakurai
Noritaka Kawasaki
Min Kyung Choo
Yurika Saitoh
Yasushi Aozuka
Pattama Singhirunnusorn
Somsak Ruchirawat
Jisnuson Svasti
Ikuo Saiki
University of Toyama
Chulabhorn Research Institute
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2005
Citation: European Journal of Pharmaceutical Sciences. Vol.25, No.1 (2005), 57-65
Abstract: Vanillin, a food flavoring agent, has been reported to show anti-mutagenic activity and to inhibit chemical carcinogenesis. In this study, we examined the effect of vanillin on the growth and metastasis of 4T1 mammary adenocarcinoma cells in BALB/c mice. Mice orally administered with vanillin showed significantly reduced numbers of lung metastasized colonies compared to controls. In vitro studies revealed that vanillin, at concentrations that were not cytotoxic, inhibited invasion and migration of cancer cells and inhibited enzymatic activity of MMP-9 secreted by the cancer cells. Vanillin also showed growth inhibitory effect towards cancer cells in vitro. However, vanillic acid, a major metabolic product of vanillin in human and rat, was not active in these in vitro activity assays. Our findings suggest that vanillin has anti-metastatic potential by decreasing invasiveness of cancer cells. Since vanillin is generally regarded as safe, it may be of value in the development of anti-metastatic drugs for cancer treatment. © 2005 Elsevier B.V. All rights reserved.
ISSN: 09280987
Appears in Collections:Scopus 2001-2005

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