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Title: Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system
Authors: Michelle Dziejman
Davide Serruto
Vincent C. Tam
Derek Sturtevant
Pornphan Diraphat
Shah M. Faruque
M. Hasibur Rahman
John F. Heidelberg
Jeremy Decker
Li Li
Kate T. Montgomery
George Grills
Raju Kucherlapati
John J. Mekalanos
Harvard Medical School
International Centre for Diarrhoeal Disease Research Bangladesh
J. Craig Venter Institute
Harvard Partners Genome Center
Brigham and Women's Hospital
University of Rochester School of Medicine and Dentistry
Novartis Immunobiological Research Institute
Mahidol University
Keywords: Multidisciplinary
Issue Date: 1-Mar-2005
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.102, No.9 (2005), 3465-3470
Abstract: Non-O1, non-O139 Vibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 strains of V. cholerae, little is known about the virulence gene content of non-O1, non-O139 strains and their phylogenetic relationship to other pathogenic V. cholerae. Comparative genomic microarray analysis of four pathogenic non-O1, non-O139 strains indicates that these strains are quite divergent from O1 and O139 strains. Genomic sequence analysis of a non-O1, non-O139 strain (AM-19226) that appeared particularly pathogenic in experimental animals suggests that this strain carries a type III secretion system (TTSS) that is related to the TTSS2 gene cluster found in a pandemic clone of Vibrio parahaemolyticus. The genes for this V. cholerae TTSS system appear to be present in many clinical and environmental non-O1, non-O139 strains, including at least one clone that is globally distributed. We hypothesize that the TTSS present in some pathogenic strains of non-O1, non-O139 V. cholerae may be involved in the virulence and environmental fitness of these strains. © 2005 by The National Academy of Sciences of the USA.
ISSN: 00278424
Appears in Collections:Scopus 2001-2005

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