Please use this identifier to cite or link to this item:
|Title:||Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis|
Yong Sung Kim
Yong Sung Kim
Hiroshima University Faculty of Medicine
Genetic Engineering Research Institute
|Keywords:||Biochemistry, Genetics and Molecular Biology;Medicine|
|Citation:||Cancer Research. Vol.55, No.20 (1995), 4549-4551|
|Abstract:||Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et aL, Proc. Natl. Acad. Sci. USA, 88:9523–9527, 1991). About 2000 Notl restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor. © 1995, American Association for Cancer Research. All rights reserved.|
|Appears in Collections:||Scopus 1991-2000|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.