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Title: Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis
Authors: Hisaki Nagai
Mathurose Ponglikitmongkol
Yong Sung Kim
Kenichi Matsubara
Hiroaki Tsumura
Mathurose Ponglikitmongkol
Yong Sung Kim
Osaka University
Hiroshima University Faculty of Medicine
Mahidol University
Genetic Engineering Research Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 15-Oct-1995
Citation: Cancer Research. Vol.55, No.20 (1995), 4549-4551
Abstract: Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et aL, Proc. Natl. Acad. Sci. USA, 88:9523–9527, 1991). About 2000 Notl restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor. © 1995, American Association for Cancer Research. All rights reserved.
ISSN: 15387445
Appears in Collections:Scopus 1991-2000

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