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Title: Mechanism-Based Development of New Antimalarials: Synthesis of Derivatives of Artemisinin Attached to Iron Chelators
Authors: Sumalee Kamchonwongpaisan
Sumpan Paitayatat
Yodhathai Thebtaranonth
Prapin Wilairat
Yongyuth Yuthavong
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-1995
Citation: Journal of Medicinal Chemistry. Vol.38, No.13 (1995), 2311-2316
Abstract: Various derivatives of artemisinin covalently linked to iron chelators were synthesized, and their antimalarial activities were evaluated. Although results show no indication that the presence of an iron chelator in the vicinity of artemisinin potentiates its action, the linked compounds prepared still retain comparable activities to that of artemisinin. © 1995, American Chemical Society. All rights reserved.
ISSN: 15204804
Appears in Collections:Scopus 1991-2000

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