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Title: Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain
Authors: Wipawan Thangnipon
Wipa Thangnipon
Pinsuda Luangpaiboon
Supranee Chinabut
Mahidol University
Division of Agricultural Toxic Substances, Thailand Department of Agriculture
Aquatic Animal Health Research Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Neuroscience
Issue Date: 1-May-1995
Citation: Neurochemical Research. Vol.20, No.5 (1995), 587-591
Abstract: The neurotoxic effects of monocrotophos on the brain of the nile tilapia fish (Oreochromis niloticus) were examined, using a static bioassay under laboratory conditions. By probit analysis the 96 h LC50value of monocrotophos was 4.9 mg/l. After 96 h exposure to acute levels of monocrotophos, the brain acetylcholinesterase (AChE) activity decreased progressively as the concentration of monocrotophos increased. In addition, four weeks following transfer to toxicant-free water after exposure to 1 mg monocrotophos, nile tilapia fish brain regained 95% of control AChE activity. The results indicate that inhibition of AChE activity in fish exposed to monocrotophos may serve as an indicator of hazard due to application of this chemical in the natural environment. © 1995 Plenum Publishing Corporation.
ISSN: 15736903
Appears in Collections:Scopus 1991-2000

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