Please use this identifier to cite or link to this item:
|Title:||Collection of cord blood stem cells for transplantation in thalassemic patients|
Chulabhorn Bone Marrow Transplant Center
|Keywords:||Biochemistry, Genetics and Molecular Biology|
|Citation:||STEM CELLS. Vol.13, No.3 S (1995), 71-75|
|Abstract:||Thalassemia is widely distributed throughout the world and is one of the major public health problems. The use of bone marrow transplantation, the only curative therapy for thalassemia, is limited because less than 30% of the patients have unaffected and HLA‐identical siblings as donors. Cord blood stem cells, an alternative source of stem cells for transplantation, have been successfully transplanted into patients with several diseases after myeloablative therapy. Twenty cord blood samples from unaffected neonates whose siblings had severe thalassemia were collected. The median volume was 80 ml. The median number of cells and colony forming units‐granulocyte‐macrophage in cord blood was 9.2 x 1018 and 3.4 x 105, respectively. Four of 20 cord blood samples had HLA‐matched to the affected siblings. One patient underwent cord blood transplantation with success; one patient is waiting for transplantation. Copyright © 1995 AlphaMed Press|
|Appears in Collections:||Scopus 1991-2000|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.