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Title: Elevated serum levels of IL-10 and IFN-γ in patients with acute Plasmodium falciparum malaria
Authors: C. Wenisch
B. Parschalk
E. Narzt
S. Looareesuwan
W. Graninger
Allgemeines KrankenHaus Wien
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1995
Citation: Clinical Immunology and Immunopathology. Vol.74, No.1 (1995), 115-117
Abstract: Serum levels of interleukin-10 (IL-10) and interferon-γ (IFN-γ)) were determined in 37 patients with acute Plasmodium falciparum malaria in Bangkok, Thailand. Serum levels of IL-10 and IFN-γ were markedly elevated in patients with malaria prior to treatment (717 ± 260 pg/ml versus 2.2 ± 1.3 pg/ml in healthy controls; 123 ± 71 pg/ml versus 29 ± 9 pg/ml, respectively; mean ± SD). Serum levels of IFN-γ and IL-10 dropped significantly during treatment and were normal 14 and 21 days, respectively, after treatment was started. Prior to therapy a correlation between serum levels of IFN-γ and IL-10 existed (r = 0.563). These results suggest that stimulatory and inhibitory cytokines for macrophage activation and/or antibody production (i.e., TH1- and TH2-type immunoreaction, respectively) are coexpressed during acute P. falciparum infection and stress the multifactorial network between host and parasite in malaria immunology. © 1995 Academic Press, Inc.
ISSN: 00901229
Appears in Collections:Scopus 1991-2000

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