Please use this identifier to cite or link to this item:
|Title:||The presence of the HLA class. II allele DPB1*0501 in ethnic Thais correlates with an enhanced vaccine‐induced antibody response to a malaria sporozoite antigen|
|Authors:||Henry A.F. Stephens|
Arthur E. Brown
H. Kyle Webster
Daniel M. Gordon
Armed Forces Research Institute of Medical Sciences, Thailand
Walter Reed Army Institute for Research
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||European Journal of Immunology. Vol.25, No.11 (1995), 3142-3147|
|Abstract:||In this study, we examined the correlation between the frequency of allelic variants of the class II human leukocyte antigen (HLA) DR, DQ and DP gene loci and the quantitative humoral immune response observed in 71 Thai volunteers, subsequent to vaccination with a conjugated subunit vaccine. This vaccine was designed to induce antibodies directed against the immunodominant repeat region of the Plasmodium falciparum circumsporozoite (CS) protein. The presence of the DPB1*0501, a relatively common allele in Asian populations, was found to be associated with high vaccine‐induced CS repeat‐specific antibody responses in the volunteers. Given the increasing focus on the use of subunit vaccines in the control of infectious diseases, consideration of the influence of class II allele frequencies in ethnically diverse recipient populations may be important. Copyright © 1995 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim|
|Appears in Collections:||Scopus 1991-2000|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.