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Title: The presence of the HLA class. II allele DPB1*0501 in ethnic Thais correlates with an enhanced vaccine‐induced antibody response to a malaria sporozoite antigen
Authors: Henry A.F. Stephens
Arthur E. Brown
Dasnayanee Chandanayingyong
H. Kyle Webster
Monchan Sirikong
Panpimon Longta
Rapeepun Vangseratthana
Daniel M. Gordon
Somboon Lekmak
Ekaraj Rungruang
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Walter Reed Army Institute for Research
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1995
Citation: European Journal of Immunology. Vol.25, No.11 (1995), 3142-3147
Abstract: In this study, we examined the correlation between the frequency of allelic variants of the class II human leukocyte antigen (HLA) DR, DQ and DP gene loci and the quantitative humoral immune response observed in 71 Thai volunteers, subsequent to vaccination with a conjugated subunit vaccine. This vaccine was designed to induce antibodies directed against the immunodominant repeat region of the Plasmodium falciparum circumsporozoite (CS) protein. The presence of the DPB1*0501, a relatively common allele in Asian populations, was found to be associated with high vaccine‐induced CS repeat‐specific antibody responses in the volunteers. Given the increasing focus on the use of subunit vaccines in the control of infectious diseases, consideration of the influence of class II allele frequencies in ethnically diverse recipient populations may be important. Copyright © 1995 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN: 15214141
Appears in Collections:Scopus 1991-2000

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