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Title: Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment
Authors: S. Krishna
S. Pukrittayakamee
W. Supanaranond
F. ter Kuile
M. Ruprah
T. Sura
N. J. White
Mahidol University
John Radcliffe Hospital
Poisons Unit
Ramathipodi Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1995
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.89, No.5 (1995), 507-509
Abstract: Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-‘blind’ study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever >38.5 >C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use. © 1995 Oxford University Press.
ISSN: 18783503
Appears in Collections:Scopus 1991-2000

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