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Title: Both HLA-B<sup>*</sup>1301 and B<sup>*</sup>1302 Exist in Asian Populations and Are Associated with Different Haplotypes
Authors: Ling Lin
Katsushi Tokunaga
Fumiaki Nakajima
Yoshihide Ishikawa
Kouichi Kashiwase
Hidenori Tanaka
Shoji Kuwata
Elena W. Sideltseva
Tatsuya Akaza
Kenji Tadokoro
Yoichi Shibata
Dasnayanee Chandanayingyong
Takeo Juji
Japanese Red Cross Medical Center
University of Tokyo
Kanagawa Red Cross Blood Center
Immunogenetics Research Centre
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1995
Citation: Human Immunology. Vol.43, No.1 (1995), 51-56
Abstract: A B13 split antigen was newly identified with three alloantisera in Japanese, and two B13 split antigens were found in a Thai family. To confirm the variation of B13 and understand the correspondence between the serologic splits and the published B13 alleles, B*1301 and B*1302, we determined the sequences of genes coding for these B13 splits. The common Japanese B13 allele was found to be B*1301, whereas another split antigen was shown to be coded by B*1302. Two B13 variants identified in a Thai individual corresponded to B*1301 and B*1302. Moreover, 57 B13-positive samples from several ethnic groups were examined using the PCR-SSO method. Differing from previous reports, both B*1301 and B*1302 were found in samples from Asian populations. These two alleles were separately associated with different antigens: HLA-B*1301 exhibited a strong association with A2, Cw10, DR12, and DQ7 antigens, whereas HLA-B*1302 was strongly associated with A30, Cw6, DR7, and DQ2 antigens. In addition, applying the PCR-SSCP method, B*1301 and B*1302 could also be simply distinguished from each other. © 1995.
ISSN: 01988859
Appears in Collections:Scopus 1991-2000

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