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|Title:||Both HLA-B<sup>*</sup>1301 and B<sup>*</sup>1302 Exist in Asian Populations and Are Associated with Different Haplotypes|
Elena W. Sideltseva
Japanese Red Cross Medical Center
University of Tokyo
Kanagawa Red Cross Blood Center
Immunogenetics Research Centre
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||Human Immunology. Vol.43, No.1 (1995), 51-56|
|Abstract:||A B13 split antigen was newly identified with three alloantisera in Japanese, and two B13 split antigens were found in a Thai family. To confirm the variation of B13 and understand the correspondence between the serologic splits and the published B13 alleles, B*1301 and B*1302, we determined the sequences of genes coding for these B13 splits. The common Japanese B13 allele was found to be B*1301, whereas another split antigen was shown to be coded by B*1302. Two B13 variants identified in a Thai individual corresponded to B*1301 and B*1302. Moreover, 57 B13-positive samples from several ethnic groups were examined using the PCR-SSO method. Differing from previous reports, both B*1301 and B*1302 were found in samples from Asian populations. These two alleles were separately associated with different antigens: HLA-B*1301 exhibited a strong association with A2, Cw10, DR12, and DQ7 antigens, whereas HLA-B*1302 was strongly associated with A30, Cw6, DR7, and DQ2 antigens. In addition, applying the PCR-SSCP method, B*1301 and B*1302 could also be simply distinguished from each other. © 1995.|
|Appears in Collections:||Scopus 1991-2000|
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