Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Differing Frequency of Autoantibodies to Glutamic Acid Decarboxylase among Koreans, Thais, and Australians with Diabetes Mellitus
Authors: T. Tuomi
P. Zimmet
M. J. Rowley
H. K. Min
A. Vichayanrat
H. K. Lee
B. D. Rhee
S. Vannasaeng
A. R.G. Humphrey
I. R. Mackay
Monash University
Baker Heart and Diabetes Institute
Seoul National University College of Medicine
Mahidol University
Malmo Central Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1995
Citation: Clinical Immunology and Immunopathology. Vol.74, No.2 (1995), 202-206
Abstract: The wide racial-geographic differences in the incidence and prevalence of insulin-dependent diabetes mellitus (IDDM) between Europids and Asian populations prompted us to compare frequencies of positivity of autoantibody to glutamic acid decarboxylase) (GAD). The patients with IDDM included 41 Koreans, 30 Thais, and 45 Australian Europids; the Koreans included 14 cases regarded as atypical IDDM by reason of a delayed requirement for insulin treatment. Autoantibodies were measured by radioimmunoprecipitation using iodinated purified porcine brain GAD. The frequency of positive tests for anti-GAD of 30% (8/27) for Koreans and 51% (20/39) for Thais was significantly lower than the 84% (38/45) for Australian Europids, even after stratifying by age of onset. Correspondingly, the mean levels of anti-GAD among seropositive cases were significantly lower for Koreans than for Australian Europids. In contrast to Thais and Australians, more than half the Koreans were diagnosed at age >20 years, but there was no significant difference in positivity for anti-GAD between those over or under the age of 20 at diagnosis. The different frequency of positivity in tests for anti-GAD among Koreans, Thais, and Australian Europids with IDDM suggests that there is a greater etiologic heterogeneity of IDDM among Asian than Europid populations, in whom autoimmune destruction of pancreatic islets predominates. © 1995 Academic Press, Inc.
ISSN: 00901229
Appears in Collections:Scopus 1991-2000

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.