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|Title:||Prognostic significance of quantitative bacteremia in septicemic melioidosis|
|Authors:||Amanda L. Walsh|
Michael D. Smith
David A.B. Dance
Nicholas J. White
Nuffield Department of Clinical Medicine
|Citation:||Clinical Infectious Diseases. Vol.21, No.6 (1995), 1498-1500|
|Abstract:||Pour-plate blood cultures were performed for 418 adult patients with suspected septicemic melioidosis in order to determine the relationship between quantitative bacterial counts in blood and mortality. Of 108 patients whose hemocultures yielded Burkholderia pseudomallei, 53% had <10 cfulmL and 24% had > 100 cfulmL. High blood bacterial counts were more common than reported previously with regard to other gram-negative septicemias and weresignificantly associated with the development ofhypotension (P =.008) and a fatal outcome (P =.0001). The overall mortality was 63% (95% CI, 53%-72%); however, counts of ≤1 cfulmL were associated with a mortality of 42% (95% CI, 28%-58%), compared with 96% (95% CI, 80%-100%) with counts of >100 cfu/mL. Heavy bacteremia (>50cfulmL) is common in septicemic melioidosis and is usually fatal. © 1995 The University of Chicago.|
|Appears in Collections:||Scopus 1991-2000|
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