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Title: Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype
Authors: Jonathan Weber
Eva Maria Fenyö
Simon Beddows
Pontiano Kaleebu
Åsa Björndal
S. Osmanov
W. Heyward
J. Esparza
B. Galvao-Castro
P. Van De Perre
E. Karita
C. Wasi
S. Sempala
B. Tugume
B. Biryahwaho
H. Rübsamen-Waigmann
H. Von Briesen
R. Esser
M. Grez
H. Holmes
A. Newberry
S. Ranjhar
P. Tomlinson
J. Bradac
Imperial College London
Karolinska Institutet
Fundacao Oswaldo Cruz
National Reference Laboratory
Mahidol University
Uganda Virus Research Institute
National Institute for Biological Standards and Control
National Institute of Allergy and Infectious Diseases
Keywords: Agricultural and Biological Sciences;Immunology and Microbiology
Issue Date: 1-Nov-1996
Citation: Journal of Virology. Vol.70, No.11 (1996), 7827-7832
Abstract: Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype- specific neutralization was observed. Most plasma tested were broadly cross- neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes.
ISSN: 0022538X
Appears in Collections:Scopus 1991-2000

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